Controlled expression of XRCC2 associated with induced DNA damage: a new hope in colorectal cancer

Genetic variants in XRCC2: new insights into colorectal cancer tumorigenesis.

Polymorphisms in DNA double-strand break repair gene XRCC2 may play an important role in colorectal cancer etiology, specifically in disease subtypes. Associations of XRCC2 variants and colorectal cancer were investigated by tumor site and tumor instability status in a four-center collaboration including three U.K. case-control studies (Sheffield, Leeds, and Dundee) and a U.S. case-control stud...

Association of CD166 expression with clinicopathologic characteristics of colorectal cancer

A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer.

An acquired genetic instability, resulting from the loss of some types of DNA repair, is an early event in the development of a subset of human cancers. The involvement of BRCA1 and BRCA2 in the homologous recombination repair (HRR) of double-strand breaks in DNA implicates this pathway in the suppression of breast cancer. A family of proteins related to human RAD51, including XRCC2, are essent...

Expression of Aldehyde Dehydrogenase 1 in Patients with Colorectal Cancer in North of Iran

Background and purpose: High cancer related mortality can be due to the presence of cancer stem cells (CSCs). Studies suggest aldehyde dehydrogenase (ALDH1) as a marker of CSCs. The aim of this study was to investigate its expression in colorectal cancer and also its association with clinicopathologic characteristics. Materials and methods: In a retrospective study, patients with colorectal ca...

new semigroup compactifications via the enveloping semigroups of associated flows

this thesis deals with the construction of some function algebras whose corresponding semigroup compactification are universal with respect to some properies of their enveloping semigroups. the special properties are of beigan a left zero, a left simple, a group, an inflation of the right zero, and an inflation of the rectangular band.